This review highlights recent advances in pathophysiology and treatment for uremic pruritus, especially\nfocusing on various interventions. Pruritus in patients on hemodialysis (HD) and peritoneal\ndialysis (PD) still remains an unresolved issue. Recently, the efficacy and safety of nalfurafine\nhydrochloride have been reported in Japan, and at present, more than thirty thousand patients\nreceive this new drug. In comparison with the efficacy of this new drug, acupuncture, a form of\ntraditional Japanese therapy, has been validated for relief of symptoms of pruritus. In this review,\nvarious interventions for relief of symptoms of pruritus as well as recent studies on its pathophysiology\nwill be introduced. This review will be helpful for treatment of pruritus in patients on\ndialyzed therapy in clinical practice.
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